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  • Writer's pictureSolomon Matzner

How Niacinamide Enhances Keratin Production

Keratin is a key structural protein in hair, skin, and nails, providing strength and resilience. Niacinamide, a form of vitamin B3, plays a significant role in enhancing keratin production, contributing to the overall health and appearance of these tissues. Here’s a detailed explanation of how niacinamide facilitates this process:

Mechanisms of Niacinamide in Keratin Production

Cellular Metabolism and Energy Production

  • Role of NAD+: Niacinamide is a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for cellular metabolism and energy production.

  • Energy for Keratinocytes: Keratinocytes, the primary cells in the epidermis responsible for producing keratin, require substantial energy to function effectively. By increasing NAD+ levels, niacinamide boosts the metabolic energy available to these cells, enhancing their capacity to synthesize keratin.

Regulation of Gene Expression

  • Activation of Sirtuins: Niacinamide influences the activity of sirtuins, a family of proteins that regulate gene expression and cellular longevity. Sirtuins modulate the expression of genes involved in keratin production, thereby promoting the synthesis of this crucial protein.

  • Transcription Factors: Niacinamide impacts transcription factors that control the expression of keratin genes. This regulation ensures that keratinocytes produce adequate amounts of keratin to maintain healthy skin, hair, and nails.

Enhancing Epidermal Barrier Function

  • Barrier Integrity: By improving the skin’s barrier function, niacinamide helps maintain an optimal environment for keratinocyte function. A robust skin barrier prevents the loss of moisture and protects against environmental damage, both of which are essential for healthy keratin production.

  • Ceramide Production: Niacinamide boosts the production of ceramides, lipids that are vital for maintaining the skin’s barrier. Healthy ceramide levels support keratinocyte function and, consequently, keratin production.

Anti-Inflammatory Effects

  • Reducing Inflammation: Chronic inflammation can impair keratinocyte function and reduce keratin production. Niacinamide’s anti-inflammatory properties help to mitigate this issue, ensuring that keratinocytes can operate optimally.

  • Healing and Repair: By reducing inflammation, niacinamide also promotes the healing and repair of damaged skin, which includes the restoration of keratin levels.

Antioxidant Properties

  • Protection from Oxidative Stress: Niacinamide’s antioxidant properties protect keratinocytes from oxidative stress and free radical damage. This protection ensures that keratinocytes remain healthy and capable of producing keratin efficiently.

  • Cellular Repair: Antioxidant effects also support the repair of damaged cells, further enhancing the overall production of keratin.

Benefits of Enhanced Keratin Production

Stronger Hair

  • Reduced Breakage: Enhanced keratin production strengthens hair strands, reducing breakage and split ends.

  • Improved Texture: Hair becomes smoother and more resilient, improving its overall texture and appearance.

Healthier Skin

  • Barrier Function: Increased keratin levels improve the skin’s barrier function, enhancing its ability to retain moisture and protect against environmental aggressors.

  • Texture and Tone: Skin appears smoother and more even-toned, with a reduction in rough patches and fine lines.

Stronger Nails

  • Reduced Brittleness: Nails become less brittle and prone to breaking, with improved strength and resilience.


Niacinamide enhances keratin production through multiple mechanisms, including boosting cellular energy production, regulating gene expression, improving the skin barrier, reducing inflammation, and providing antioxidant protection. These effects contribute to stronger hair, healthier skin, and more resilient nails, making niacinamide a valuable ingredient in both skincare and haircare products. By incorporating niacinamide into your routine, you can support the natural production of keratin and improve the overall health and appearance of your hair, skin, and nails.

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BSP Sourcing is a trusted sourcing partner for chemicals and raw materials offering Strategic Sourcing and Supply Chain Solutions across industry segments. BSP Sourcing is part of BioAktive Group Inc, a US company supplying best in class ingredients, raw materials and solutions at the intersection of chemicals and life sciences. For more information, please email us or

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Solomon Matzner


BioAktive Group Inc

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